RAF Typhoon FGR4s have operated alongside French warplanes in a coordinated attack on an subterranean weapons facility in Syria operated by the Daesh militant organization, per a report from the British defence ministry.
The location, located using intelligence, was believed to be housing weapons and explosive materials, the release indicated, and was positioned in mountains just north of the historic site of Palmyra in the heart of Syria.
"Our aircraft utilized precision-guided Paveway IV munitions to target a series of entry passages leading to the depot... preliminary assessments indicate the target was engaged successfully," the MoD said.
There was no evidence of any civilian casualties in the operation on Saturday evening and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager tanker plane.
The Islamic State group - alternatively referred to as Daesh - imposed jihadist rule over significant areas in Syria and Iraq until 2019.
"This action underscores the UK's leading role, and determination to operate in unison with our partners, to eliminate any revival of IS and their violent and radical beliefs in the Middle East," UK Defence Secretary the minister said.
RAF aircraft have performed surveillance missions over Syria to "deter any attempted resurgence" of the group following its defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank every member of our armed forces participating in this operation for their expertise and their bravery," he added. "They were among numerous British troops stationed over the holidays. This mission, to remove militants who threaten our security, demonstrates how our armed forces are ready to step up, continuously, ensuring Britain's security at home and influential overseas."
Last December, the United States armed forces conducted what it described as a "major assault" on Islamic State objectives in Syria, following an assault killed two American soldiers and a local interpreter in Palmyra.
The UN estimates IS still has an estimated 5,000 to 7,000 fighters in Iraq and Syria.